The permanent store opened this November at 44 Carnaby Street, after the womenswear brand previously launched several pop-ups on the same street.
The store is the first to feature a design studio and will sell current collections and products for the Christmas season.
Key collections include partywear, bridalwear and accessories, with price points ranging from £195 to £795.
Rixo also has stores on London’s King’s Road and in Marylebone.
Henrietta Rix and Orlagh McCloskey, Rixo co-founders, said: “We are thrilled to be opening Rixo’s third London location on Carnaby Street. We had a successful pop up here a few years back, and we’re really excited to be back on such a historic London street.”
Samantha Bain-Mollison, retail director at property firm Shaftesbury, added: "We are so excited to welcome the popular fashion brand Rixo to Carnaby. The permanent store is located in prime position on Carnaby Street after several successful pop-ups in the Shaftesbury portfolio. We hope the Carnaby customer can enjoy shopping the brand's modern day vintage inspired styles.
“The brand fits in perfectly with Shaftesbury’s sustainable business model and we are looking forward to them joining us in the area.”